What is Avanafil (Stendra)?


Avanafil (Stendra)

Avanafil (Stendra) is a treatment for erectile dysfunction. Specifically, it is a PDE5 inhibitor. It works by inhibiting the cGMP-specific enzyme phosphodiesterase type 5 (PDE5 in short), which can regulate blood flow to the erectile tissues of the penis.

When sexually aroused, the body increases blood flow to the penis. Avanafil, the active ingredient in Stendra, triggers the release of nitric oxide from the cavernous tissue, which relaxes the smooth muscles of the cavernous body, allowing more blooded to enter them, helping them to harden.

Like other erectile dysfunction drugs, Stendra does not cause accidental erections. Conversely, erections become easier only if you are already sexually aroused.

Stendra comes in pill form in various dosages. The most common dosages are 50mg, 100mg and 200mg, each of which is intended to be used 15-30 minutes before sexual activity, depending on the dosage. A typical dose of Stendra is sufficient for up to 6 hours after taking the medicine.

Stendra, a second-generation erectile dysfunction drug.

Use of Avanafil

Erectile Dysfunction

Avanafil is used to treat sexual problems in men (impotence or erectile dysfunction-ED). When combined with sexual stimulation, Avanafil helps men maintain and maintain an erection by increasing blood flow to the penis.

This medicine does not protect against sexually transmitted diseases. To reduce the risk of infection, always use an effective barrier method (latex or polyurethane condom/dental pad) during sexual activity. Ask your pharmacist for more information.

How does the Avanafil work?

Like sildenafil, tadalafil, and vardenafil, avanafil tablets increase the amount of cGMP (cyclic Guanosine Monophosphate) inside the penis by inhibiting the enzyme type 5 phosphodiesterase. This releases nitric oxide, which increases blood flow inside the penis. So, this ultimately leads to an erection of the penis during sexual intercourse.

Common treatments for erectile dysfunction include drugs such as sildenafil, tadalafil, and vardenafil. Avanafil is a highly selective inhibitor of the enzyme PDE5, the main enzyme that causes erectile dysfunction. Inhibition of PDE5 increases blood flow to the penis, resulting in an erection. Typical drugs are much more selective inhibitors of PDE5. Along with PDE5, it inhibits other PDE enzymes such as PDE1,3, 6 and 11, leading to side effects such as vision problems, low blood pressure, and more.

For the same reason, Avanafil’s onset of action is much faster (15 minutes) compared to other drugs and provides a long-lasting erection for good penetration during intercourse.

How to Use Avanafil?

Before you start taking avanafil and whenever you receive it again, read the patient information leaflets if your pharmacist provides it. If you have any other questions, contact your pharmacist or doctor.

In general, take this medicine by mouth with or without food as directed by your doctor as needed. This drug is available in different dosages. Depending on the dosage, take Avanafil 15 or 30 minutes before sex. Follow your doctor’s instructions carefully. Do not take more than once medicine a day.

The dosage depends on your condition, your response to treatment, and other medications you are taking. Tell your doctor and pharmacist about all the products you use (including prescription drugs, over-the-counter medicines, and herbal products).

Tell your doctor if your condition doesn’t improve.

Side Effects

  • Nausea
  • Dyspepsia
  • Diarrhea
  • Constipation
  • Hot flashes
  • Electrocardiographic alterations
  • Hypertension
  • Headache
  • Nasal congestion
  • Sinusitis
  • Upper airway infections
  • Bronchitis
  • Vertigo
  • Back pain
  • Arthralgia
  • Nasopharyngitis


Missed dose

This medicine is used as needed, so, you are less likely to miss a dose. If you are on a schedule for this drug, take the missed dose as soon as you remember. When it’s time for your next dose, skip the missed dose. Don’t take it twice to catch up.


In case of overdose, seek emergency treatment or see a doctor.

Avanafil Medicine



Avanafil medicine is not for pregnant women.


Avanafil medicine is not for women who are breastfeeding.

Penile deformity

Avanafil medicine should be used with caution in patients with physical deformities of the penis that may be caused by curvature, spongy fibrosis, or Peyronie’s disease. The risk of permanent loss of sexual function is very high when this drug is used in patients suffering from these conditions. Depending on the patient’s clinical condition, you should consider replacing it with an appropriate alternative.

Heart disease

Avanafil medicine should be used with great care if you have heart or vascular disease. It is not recommended for use in patients who have had a heart attack, stroke, or life-threatening arrhythmia in the past 6 months. The use of this drug is not recommended if your doctor has told you not to engage in sexual activity due to an increased risk of serious heart side effects.

Other drugs

Avanafil medicine is not recommended for patients taking medications such as nitroglycerin and riociguat due to an increased risk of serious side effects. This drug should be used with caution in patients taking medication to treat high blood pressure, heart disease, etc.

Vision loss

Avanafil medicine can cause sudden loss of vision in one or both eyes. It can also impair color discrimination. Therefore, patients with a rare retinal genetic disorder called retinitis pigmentosa are at increased risk of vision loss and should be used with extreme caution. Stop using this medicine and call your doctor immediately if you experience any of these symptoms.

Hearing loss

Avanafil medicine can cause sudden hearing loss and cause ringing or ringing in the ears. Stop using this medicine and call your doctor immediately if you experience any of these symptoms. In some cases, it may be necessary to replace it with an appropriate replacement depending on the clinical condition.

Use for children

The use of avanafil medicine is not recommended for patients under the age of 18, as the safety and effectiveness of the use of this drug has not been clinically proven.

Use in women

Avanafil medicine is not for women.

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